Dexmedetomidine versus nalbuphine in prevention of emergence agitation following adenotonsillectomy in pediatrics

Background: Adenotonsillectomy is considered one of the most common surgical procedures in preschool age children. Postoperative emergence agitation (EA) is a major problem that faces anesthesiologist and can be managed by different drugs as opioids, sedatives and propofol. The present prospective,...

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Bibliographic Details
Published in:Egyptian journal of anaesthesia 2020-01, Vol.36 (1), p.24-29
Main Authors: Elagamy, Ashraf Elsayed, Mahran, Mostafa Gamal, Mahmoud, Amr Zaki
Format: Article
Language:English
Subjects:
adenotonsillectomy
Agitation
dexmedetomidine
nalbuphine
pediatrics
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Summary:Background: Adenotonsillectomy is considered one of the most common surgical procedures in preschool age children. Postoperative emergence agitation (EA) is a major problem that faces anesthesiologist and can be managed by different drugs as opioids, sedatives and propofol. The present prospective, randomized double blinded study was designed to evaluate the effect of intraoperative 0.5 µg/kg dexmedetomidine infusion versus 0.1 mg/kg nalbuphine IV for prevention of postoperative emergence agitation. Methods: After ethical committee's approval and written informed consent, 160 patients were enrolled in the study, 80 in each group. Patients enrolled in the study were randomized into dexmedetomidine 0.5 µg/kg infusion (DEX group) or nalbuphine 0.1 mg/kg IV (NAL group). Both groups were under standard anesthetic regimen with sevoflurane anesthesia. Postoperative measurements included pediatric anesthesia emergence delirium (PAED) score, Ramsay sedation score, hemodynamic changes at arrival to post anesthesia care unit (PACU) 5, 10 minutes then every 10 minutes till discharge from PACU. Results: After ethical committee approval and written informed consent, 160 patients were enrolled in the study, 80 in each group. PAED score was significantly higher in NAL group than DEX group (13(12-16) vs. 12(11-13), respectively (p value
ISSN:1110-1849
1687-1804
1110-1849
DOI:10.1080/11101849.2020.1728865