Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis

The environment can modify the physiology and body protective function of the skin. Propolis (PRP) and curcumin (CUR) possess important antioxidant and antimicrobial properties, and they can be administered in a combined way and using photodynamic therapy (PDT). Emulgels can control drug release due...

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Published in:Pharmaceutical development and technology 2023-07, Vol.28 (6), p.559-570
Main Authors: dos Santos, Rafaela Said, Bassi da Silva, Jéssica, Vecchi, Camila Felix, da Silva Souza Campanholi, Katieli, Rosseto, Hélen Cassia, de Oliveira, Mariana Carla, Garcia, Francielle Pelegrin, Balbinot, Rodolfo Bento, de Castro Hoshino, Lidiane Vizioli, Nakamura, Tânia Ueda, Nakamura, Celso Vataru, Baesso, Mauro Luciano, Caetano, Wilker, Bruschi, Marcos Luciano
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
antioxidant
Antioxidants - pharmacology
Curcumin
Development
drug delivery
emulsion
formulation
Gels - chemistry
Propolis
skin permeation
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Summary:The environment can modify the physiology and body protective function of the skin. Propolis (PRP) and curcumin (CUR) possess important antioxidant and antimicrobial properties, and they can be administered in a combined way and using photodynamic therapy (PDT). Emulgels can control drug release due to the physicochemical properties of the gel and the emulsion. They constitute a good strategy for achieving an improved platform for the combined delivery of PRP and CUR. There are no other studies of emulgels composed of PRP and CUR and their performance as antimicrobial and skin healing using or not PDT. This study aimed to investigate the effect of Carbopol 934 P (C934P), 974 P (C974P) or polycarbophil (PC) on physicochemical stability, antioxidant activity, drug release profile, antimicrobial activity, and ex vivo skin permeation and retention of emulgels containing PRP and CUR. Formulations containing C974P or PC displayed improved stability and antioxidant activity. They displayed activity against Staphylococcus aureus and modified (extended) drug release, governed mainly by non-Fickian anomalous transport. C974P and PC resulted in improved emulgels for combined CUR and PRP delivery, allowing the drugs to cross the stratum corneum, and permeate the epidermis, reaching the dermis. The selected emulgels are candidates for further studies to prove their action and benefits to skin health.
ISSN:1083-7450
1097-9867
DOI:10.1080/10837450.2023.2217536