Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia

To assess changes in expression of renal epithelial sodium channel (ENaC) and NEDD4L, a ubiquitin ligase, in urinary extracellular vesicles (UEV) of pre-eclamptic women compared to normal pregnant controls. Urine was collected from pre-eclamptic women (PE, n = 20) or during normal pregnancy (NP, n =...

Full description

Saved in:
Bibliographic Details
Published in:Hypertension in pregnancy 2023-12, Vol.42 (1), p.2232029-2232029
Main Authors: Leung, P.Y.M., Katerelos, M, Choy, S., Cook, N, Lee, M, Paizis, K, Abboud, A, Manning, J. A., Mount, P.F, Power, D.A
Format: Article
Language:English
Subjects:
epithelial sodium channel
NEDD4L
Pre-eclampsia
ubiquitin ligase
urinary extracellular vesicles
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To assess changes in expression of renal epithelial sodium channel (ENaC) and NEDD4L, a ubiquitin ligase, in urinary extracellular vesicles (UEV) of pre-eclamptic women compared to normal pregnant controls. Urine was collected from pre-eclamptic women (PE, n = 20) or during normal pregnancy (NP, n = 20). UEV were separated by differential ultracentrifugation. NEDD4L, α-ENaC and γ-ENaC were identified by immunoblotting. There was no difference in the expression of NEDD4L (p = 0.17) and α-ENaC (p = 0.10). PE subjects showed increased expression of γ-ENaC by 6.9-fold compared to NP (p 
ISSN:1064-1955
1525-6065
DOI:10.1080/10641955.2023.2232029