Interactions of Cocaine with Nimodipine: A Brief Report

This double blind, placebo controlled study of acute calcium chan nel antagonist use during cocaine administration in ve patients found that 60 mg of nimodipine treatment attenuated the systolic, but not diastolic, blood pressure effects of cocaine. In three sub jects, a 90 mg dose of nimodipine sho...

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Bibliographic Details
Published in:The American journal on addictions 1999, Vol.8 (1), p.77-81
Main Authors: Kosten, Thomas R., Woods, Scott W., Rosen, Marc I., Pearsall, H. Rowland
Format: Article
Language:English
Subjects:
Adult
Calcium Channel Blockers - metabolism
Cocaine - pharmacology
Dose-Response Relationship, Drug
Double-Blind Method
Drug Interactions
Female
Humans
Male
Middle Aged
Nimodipine - metabolism
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Summary:This double blind, placebo controlled study of acute calcium chan nel antagonist use during cocaine administration in ve patients found that 60 mg of nimodipine treatment attenuated the systolic, but not diastolic, blood pressure effects of cocaine. In three sub jects, a 90 mg dose of nimodipine showed a greater attenuation than that of 60 mg. Subjective effects of cocaine were not altered by either dose of nimodipine. Am J Addict 1999; 8:77 81
ISSN:1055-0496
1521-0391
DOI:10.1080/105504999306117