Bryophyllum pinnatum Inhibits Angiotensin Converting Enzyme and Arginase Activities in Sodium Flouride Induced Hypertensive Rats

Background: This study investigated the Bryophyllum pinnatum live plant fractions' effects on the activities of angiotensin-converting-enzyme (ACE), arginase, blood pressure, and biochemical parameters in sodium fluoride (NaF)-induced hypertensive rats. The results revealed that diastolic blood...

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Published in:Journal of herbs, spices & medicinal plants spices & medicinal plants, 2023-10, Vol.29 (4), p.375-391
Main Authors: Adetunji, Juliana B., Agbolade, Abigail O., Iyoha, Alex E., Adewale, Omowumi O., Adefegha, Adeniyi S., Salaudeen, Waliyat O.
Format: Article
Language:English
Subjects:
Acetic acid
Angiotensin
Arginase
Biomarkers
Blood pressure
Bryophyllum pinnatum
Catalase
Conversion
Ethyl acetate
Glutathione
Heart rate
Hexanes
Hypertension
malondialdehyde
n-Hexane
Nitric oxide
Peptidyl-dipeptidase A
Sodium
Sodium fluoride
Superoxide dismutase
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Summary:Background: This study investigated the Bryophyllum pinnatum live plant fractions' effects on the activities of angiotensin-converting-enzyme (ACE), arginase, blood pressure, and biochemical parameters in sodium fluoride (NaF)-induced hypertensive rats. The results revealed that diastolic blood pressure (DBP), systolic blood pressure (SBP), mean arterial pressure (MAP), heart rate (HR), and arginase activity were reduced with increased nitric oxide level compared to hypertensive rats. The aqueous fraction (AQF), n-hexane fraction (NHF), and ethyl acetate fraction (EAF) boosted superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) levels with reduction in malondialdehyde (MDA) of hypertensive-treated rats. NHF portends the capability to inhibit ACE and arginase activities and enhanced the antioxidant biomarkers.
ISSN:1049-6475
1540-3580
DOI:10.1080/10496475.2023.2184897