Protective role of lactic acid bacteria and yeasts as dietary carcinogen-binding agents - a review

The importance of food contaminants in the link between diet and cancer has been widely demonstrated. Therefore, different physical and chemical strategies for the control of human exposure to such dietary carcinogens has been explored; however, most of these strategies are complex, costly, and have...

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Published in:Critical reviews in food science and nutrition 2022, Vol.62 (1), p.160-180
Main Authors: Cuevas-González, P. F., González-Córdova, A. F., Vallejo-Cordoba, B., Aguilar-Toalá, J. E., Hall, F. G., Urbizo-Reyes, U. C., Liceaga, A. M., Hernandez-Mendoza, A., García, H. S.
Format: Article
Language:English
Subjects:
Bacteria
Binders (materials)
Binding
binding agents
Bioavailability
Biocompatibility
cancer
Carcinogens
Carcinogens - toxicity
Contaminants
Diet
Fermentation
Food contamination
Humans
In vivo methods and tests
Lactic acid
Lactic acid bacteria
Lactobacillales
Lactobacillus
Microorganisms
Neoplasms
Saccharomyces cerevisiae
Toxicity
Yeast
Yeasts
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Summary:The importance of food contaminants in the link between diet and cancer has been widely demonstrated. Therefore, different physical and chemical strategies for the control of human exposure to such dietary carcinogens has been explored; however, most of these strategies are complex, costly, and have low efficiency which limited their applications. Hence, microbiological methods have been receiving more attention. Recent in vitro and in vivo studies have indicated that lactic acid bacteria (LAB) and yeast may act as dietary carcinogen-binding agents. This review describes the promising protective role of strains belonging mainly to the Lactobacillus, Bifidobacterium and Saccharomyces genera by acting as dietary carcinogen-binding agents. This property suggests that these microorganisms may have a protective role by reducing the bioaccessibility of dietary carcinogens, thereby decreasing their toxic effects. The mechanisms by which the binding process takes place have not been completely elucidated; thus, the possible underlying mechanisms and factors influencing carcinogens-binding will be addressed.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2020.1813685