Metabolomics-assisted biotechnological interventions for developing plant-based functional foods and nutraceuticals

Today, the dramatic changes in types of food consumed have led to an increased burden of chronic diseases. Therefore, the emphasis of food research is not only to ensure quality food that can supply adequate nutrients to prevent nutrition related diseases, but also to ensure overall physical and men...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2018-07, Vol.58 (11), p.1791-1807
Main Authors: Kumar, Arun, Mosa, Kareem A., Ji, Liyao, Kage, Udaykumar, Dhokane, Dhananjay, Karre, Shailesh, Madalageri, Deepa, Pathania, Neemisha
Format: Article
Language:English
Subjects:
Alkaloids - analysis
Biotechnology
Chronic illnesses
Databases, Factual
Dietary Supplements - analysis
Exploitation
Fatty Acids - analysis
Food
Food plants
Food quality
Functional Food - analysis
Functional foods & nutraceuticals
Functional foods and nutraceuticals
Gene expression
Genome editing
Genome, Plant
Genomes
Health
Humans
metabolic engineering
metabolic pathway regulation
Metabolites
Metabolomics
metabolomics assisted breeding
Nutrients
Nutrition
Phytochemicals - analysis
Plant breeding
Plants (botany)
Plants - chemistry
Plants, Genetically Modified - genetics
Polyphenols - analysis
secondary metabolites
Technology
Terpenes - analysis
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Summary:Today, the dramatic changes in types of food consumed have led to an increased burden of chronic diseases. Therefore, the emphasis of food research is not only to ensure quality food that can supply adequate nutrients to prevent nutrition related diseases, but also to ensure overall physical and mental-health. This has led to the concept of functional foods and nutraceuticals (FFNs), which can be ideally produced and delivered through plants. Metabolomics can help in getting the most relevant functional information, and thus has been considered the greatest -OMICS technology to date. However, metabolomics has not been exploited to the best potential in plant sciences. The technology can be leveraged to identify the health promoting compounds and metabolites that can be used for the development of FFNs. This article reviews (i) plant-based FFNs-related metabolites and their health benefits; (ii) use of different analytic platforms for targeted and non-targeted metabolite profiling along with experimental considerations; (iii) exploitation of metabolomics to develop FFNs in plants using various biotechnological tools; and (iv) potential use of metabolomics in plant breeding. We have also provided some insights into integration of metabolomics with latest genome editing tools for metabolic pathway regulation in plants.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2017.1285752