Two new milbemycin derivatives from a genetically engineered strain Streptomyces bingchenggensis

Two new milbemycin derivatives, milbemycin M (1) and milbemycin N (2), were isolated from the culture of a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were elucidated through the interpretation of NMR and HR-ESI-MS spectroscopic data, as well as comparison with...

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Bibliographic Details
Published in:Journal of asian natural products research 2021-07, Vol.23 (7), p.660-665
Main Authors: Li, Jian-Song, Qi, Huan, Zhang, Shao-Yong, Xiang, Wen-Sheng, Zhang, Li-Qin, Wang, Hai-Yan, Hao, Zhi-Kui, Wang, Ji-Dong
Format: Article
Language:English
Subjects:
acaricidal and nematocidal activities
Genetic engineering
Genetically engineered strain
Milbemycin
milbemycin derivatives
NMR
Nuclear magnetic resonance
Streptomyces
Streptomyces bingchenggensis BCJ60
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Summary:Two new milbemycin derivatives, milbemycin M (1) and milbemycin N (2), were isolated from the culture of a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were elucidated through the interpretation of NMR and HR-ESI-MS spectroscopic data, as well as comparison with previous reports. The acaricidal and nematicidal activities of them against Tetranychus cinnabarinus and Bursaphelenchus xylophilus were tested. The results showed that compounds 1-2 possessed potent acaricidal and nematocidal activities.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2020.1783656