Polyketides with quorum sensing inhibitory activity from the marine-derived fungus Aspergillus sp. ZF-79

Seven compounds were isolated from a marine-derived fungus Aspergillus sp. ZF-79, including three new polyketides (1-3), named asperochrins D-F, along with four known compounds 4-7. Their structures were determined on the basis of spectroscopic methods. All the compounds were tested for quorum sensi...

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Bibliographic Details
Published in:Journal of asian natural products research 2020-11, Vol.22 (11), p.999-1005
Main Authors: Zhang, Fei, Kong, Fan-Dong, Ma, Qing-Yun, Xie, Qing-Yi, Zhou, Li-Man, Zhao, You-Xing, Guo, Lei
Format: Article
Language:English
Subjects:
Aspergillus
Aspergillus sp
Fungi
Minimum inhibitory concentration
Polyketides
Quorum sensing
quorum sensing inhibitory activity
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Summary:Seven compounds were isolated from a marine-derived fungus Aspergillus sp. ZF-79, including three new polyketides (1-3), named asperochrins D-F, along with four known compounds 4-7. Their structures were determined on the basis of spectroscopic methods. All the compounds were tested for quorum sensing inhibitory (QSI) activity. Compounds 1, 3, 4, 5, and 6 exhibited QSI activity against Chromobacterium violaceum CV026 with MIC values of 50, 100, 50, 50, and 6.25 μM, respectively.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2019.1670647