Alkaloids with antioxidant activities from Aconitum handelianum

A new C 20 -diterpenoid alkaloid handelidine (1) and twenty-seven known alkaloids (2-28) were isolated from the roots of Aconitum handelianum. Their structures were established on the basis of extensive spectroscopic analyses. The study indicated that denudatine-type C 20 -diterpenoid alkaloids with...

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Bibliographic Details
Published in:Journal of asian natural products research 2016-06, Vol.18 (6), p.603-610
Main Authors: Yin, Tian-Peng, Cai, Le, Xing, Yun, Yu, Jing, Li, Xue-Jiao, Mei, Rui-Feng, Ding, Zhong-Tao
Format: Article
Language:English
Subjects:
Aconitine - chemistry
Aconitum - chemistry
Aconitum handelianum
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
antioxidant
Antioxidants
Antioxidants - chemistry
Antioxidants - isolation & purification
Antioxidants - pharmacology
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
diterpenoid alkaloid
Drugs, Chinese Herbal - chemistry
handelidine
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oxidation-Reduction
Plant Roots - chemistry
Ranunculaceae
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Summary:A new C 20 -diterpenoid alkaloid handelidine (1) and twenty-seven known alkaloids (2-28) were isolated from the roots of Aconitum handelianum. Their structures were established on the basis of extensive spectroscopic analyses. The study indicated that denudatine-type C 20 -diterpenoid alkaloids with vicinal-triol system and benzyltetrahydroisoquinoline alkaloids exhibited significant antioxidant activities measured by three antioxidant test systems. The aconitine-type C 19 -diterpenoid alkaloids could serve as potential secondary antioxidants for their strong binding effects to metal ions.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2015.1114473