A randomized split-face clinical trial of conventional vs indoor-daylight photodynamic therapy for the treatment of multiple actinic keratosis of the face and scalp and photoaging

Recently, indoor daylight photodynamic therapy (idl-PDT) has been developed; however, its efficacy and tolerability remain to be assessed. This is a not-inferiority study to compare treatment outcomes of cPDT with a red LED lamp and idlPDT with a polychromatic white LED lamp in adult patients affect...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2022-05, Vol.33 (4), p.2250-2256
Main Authors: Arisi, M., Rossi, M. T., Spiazzi, L., Guasco Pisani, E., Venturuzzo, A., Rovati, C., Tomasi, C., Venturini, M., Calzavara-Pinton, P. G.
Format: Article
Language:English
Subjects:
actinic keratosis
indoor-daylight
PDT
photoaging
photodynamic therapy
split-face
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Summary:Recently, indoor daylight photodynamic therapy (idl-PDT) has been developed; however, its efficacy and tolerability remain to be assessed. This is a not-inferiority study to compare treatment outcomes of cPDT with a red LED lamp and idlPDT with a polychromatic white LED lamp in adult patients affected by symmetrical AKs of face and/or scalp. In this comparative, intra-patient, split-face, randomized clinical trial forty-three adult patients were enrolled. Two contralateral and symmetrical target areas of the face and/or scalp harboring at least 5 AKs were selected and randomized 1:1 to treatment with cPDT and idlPDT. The AKs number and cumulative area were assessed at baseline (T0). Efficacy and cosmetic outcome were assessed 3 months after treatment (T1). Total AKs number and area reduced significantly with both idlPDT (p 
ISSN:0954-6634
1471-1753
DOI:10.1080/09546634.2021.1944594