Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice

Age-related skin thinning is correlated with a decrease in the content of collagen in the skin. Accumulating evidence suggests that collagen peptide (CP) and vitamin C (VC) transcriptionally upregulate type I collagen in vivo. However, the additive effects of CP and VC on age-related skin changes re...

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Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2014-07, Vol.78 (7), p.1212-1220
Main Authors: Shibuya, Shuichi, Ozawa, Yusuke, Toda, Toshihiko, Watanabe, Kenji, Tometsuka, Chisa, Ogura, Takayuki, Koyama, Yoh-ichi, Shimizu, Takahiko
Format: Article
Language:English
Subjects:
Aging - pathology
Animals
Ascorbic Acid - pharmacology
Ascorbic Acid - therapeutic use
Atrophy - drug therapy
Collagen - chemistry
collagen peptide
Drug Synergism
Fibroblasts - drug effects
Fibroblasts - metabolism
Fibroblasts - pathology
Male
Mice
Oxidative Stress - drug effects
Peptide Fragments - pharmacology
Peptide Fragments - therapeutic use
Phenotype
proton-coupled oligopeptide transporter
Skin - drug effects
Skin - metabolism
Skin - pathology
Skin - physiopathology
skin atrophy
superoxide dismutase
Superoxide Dismutase - deficiency
Superoxide Dismutase-1
Transcriptome - drug effects
vitamin C
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Summary:Age-related skin thinning is correlated with a decrease in the content of collagen in the skin. Accumulating evidence suggests that collagen peptide (CP) and vitamin C (VC) transcriptionally upregulate type I collagen in vivo. However, the additive effects of CP and VC on age-related skin changes remain unclear. We herein demonstrate that CP and a VC derivative additively corrected age-related skin thinning via reduced oxidative damage in superoxide dismutase 1 (Sod1)-deficient mice. Co-treatment with these compounds significantly normalized the altered gene expression of Col1a1, Has2, and Ci1, a proton-coupled oligopeptide transporter, in Sod1 −/− skin. The in vitro analyses further revealed that collagen oligopeptide, a digestive product of ingested CP, significantly promoted the bioactivity of the VC derivative with respect to the migration and proliferation of Sod1 −/− fibroblasts. These findings suggest that combined treatment with CP and VC is effective in cases of age-related skin pathology. Co-treatment of collagen peptide and vitamin C additively improve aging-like skin atrophy in mice.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2014.915728