EFFECT OF FLOW RATE ON PARTICLE DEPOSITION IN A REPLICA OF A HUMAN NASAL AIRWAY

Charge-coupled device (CCD) imaging technology was used to observe how the spatial deposition patterns of inhaled aerosols changed as a function of rate of airflow through the airway. This technology allows the experimenter to measure local particle deposition patterns of different sized fluorescent...

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Bibliographic Details
Published in:Inhalation toxicology 2001, Vol.13 (2), p.109-127
Main Authors: Zwartz, G J, Guilmette, R A
Format: Article
Language:English
Subjects:
Aerosols
Electronics
Humans
Models, Anatomic
Nasal Cavity - anatomy & histology
Nasal Cavity - physiology
Occupational Exposure
Particle Size
Pulmonary Ventilation - physiology
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Summary:Charge-coupled device (CCD) imaging technology was used to observe how the spatial deposition patterns of inhaled aerosols changed as a function of rate of airflow through the airway. This technology allows the experimenter to measure local particle deposition patterns of different sized fluorescent particles at different flow rates in a full-scale multisection replica of a human nasal airway. Total particle deposition efficiencies and particle deposition patterns were measured in the nasal airway for 5.5-µm-diameter particles at constant flow rates of 10, 20, 30, and 40 L/min. Images of fluorescing particles on each plate of the exposed model were taken with a CCD camera and combined to form three-dimensional particle deposition patterns. Total particle deposition efficiency as measured with the model was found to be consistent with in vivo data. Impaction was found to be the dominant mechanism by which 5.5-µm-diameter particles deposit within the model, in agreement with published inhalation data.
ISSN:0895-8378
1091-7691
DOI:10.1080/089583701300001050