Inhibitory effects of vorinostat (SAHA) against food-borne pathogen Salmonella enterica serotype Kentucky mixed culture biofilm with virulence and quorum-sensing relative expression

Salmonella is a food-borne microorganism that is also a zoonotic bacterial hazard in the food sector. This study determined how well a mixed culture of Salmonella Kentucky formed biofilms on plastic (PLA), silicon rubber (SR), rubber gloves (RG), chicken skin and eggshell surfaces. In vitro interact...

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Published in:Biofouling (Chur, Switzerland) Switzerland), 2023-07, Vol.39 (6), p.617-628
Main Authors: Roy, Pantu Kumar, Ha, Angela Ji-Won, Nahar, Shamsun, Hossain, Md. Iqbal, Ashrafudoulla, Md, Toushik, Sazzad Hossen, Mizan, Md. Furkanur Rahaman, Kang, Iksoon, Ha, Sang-Do
Format: Article
Language:English
Subjects:
Biofilms
Chickens
Egg shells
Food
Food industry
food surfaces
Food-contact surfaces
Foodborne pathogens
Foods
Gene expression
Gloves
Histone deacetylase
Histones
Inhibitors
LuxS protein
Minimum inhibitory concentration
Mixed culture
Pathogens
Rubber
SAHA
Salmonella
Salmonella Kentucky
Skin
Virulence
Vorinostat (suberoylanilide hydroxamic acid
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Summary:Salmonella is a food-borne microorganism that is also a zoonotic bacterial hazard in the food sector. This study determined how well a mixed culture of Salmonella Kentucky formed biofilms on plastic (PLA), silicon rubber (SR), rubber gloves (RG), chicken skin and eggshell surfaces. In vitro interactions between the histone deacetylase inhibitor-vorinostat (SAHA)-and S. enterica serotype Kentucky were examined utilizing biofilms. The minimum inhibitory concentration (MIC) of SAHA was 120 µg mL −1 . The addition of sub-MIC (60 µg mL −1 ) of SAHA decreased biofilm formation for 24 h on PLA, SR, RG, Chicken skin, and eggshell by 3.98, 3.84, 4.11, 2.86 and 3.01 log (p 
ISSN:0892-7014
1029-2454
DOI:10.1080/08927014.2023.2242263