Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population

Significant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating the association between diurnal preference, using the morningness-eveningness questionnaire (MEQ),...

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Bibliographic Details
Published in:Chronobiology international 2017-01, Vol.34 (2), p.269-272
Main Authors: Egan, Kieren J., Campos Santos, Hadassa, Beijamini, Felipe, Duarte, Núbia E., Horimoto, Andréa R. V. R., Taporoski, Tâmara P., Vallada, Homero, Negrão, André B., Krieger, José E., Pedrazzoli, Mário, Knutson, Kristen L., Pereira, Alexandre C., von Schantz, Malcolm
Format: Article
Language:English
Subjects:
Admixture
Adult
African Continental Ancestry Group - genetics
American Native Continental Ancestry Group
Brazil
chronotype
Circadian Rhythm
Cohort Studies
diurnal preference
Ethnic Groups
European Continental Ancestry Group - genetics
Female
Gene Frequency
Homeostasis
Humans
Indians, North American - genetics
Male
Medicin och hälsovetenskap
Middle Aged
Polymorphism, Genetic
Rural Population
Sleep
sleep homeostasis
Surveys and Questionnaires
Urban Population
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Summary:Significant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating the association between diurnal preference, using the morningness-eveningness questionnaire (MEQ), and genetic ancestry within the Baependi Heart Study cohort, a highly admixed Brazilian population based in a rural town. Analysis was performed using measures of ancestry, using the Admixture program, and MEQ from 1,453 individuals. We found an association between the degree of Amerindian (but not European of African) ancestry and morningness, equating to 0.16 units for each additional percent of Amerindian ancestry, after adjustment for age, sex, education, and residential zone. To our knowledge, this is the first published report identifying an association between genetic ancestry and MEQ, and above all, the first one based on ancestral contributions within individuals living in the same community. This previously unknown ancestral dimension of diurnal preference suggests a stratification between racial/ethnic groups in an as yet unknown number of genetic polymorphisms.
ISSN:0742-0528
1525-6073
1525-6073
DOI:10.1080/07420528.2016.1265979