Drug Release Kinetics of Spray-Dried Chitosan Microspheres

The aim of this article was to investigate the drug release kinetics of spray-dried chitosan microspheres using various kinetic models. The mean particle size and encapsulation efficiency of cross-linked chitosan microspheres was between 3.8 and 4.2 μm and 96.3 and 98.7%, respectively. Spray-dried c...

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Bibliographic Details
Published in:Drying technology 2006-07, Vol.24 (6), p.769-776
Main Authors: Liu, Chengsheng, Desai, Kashappa Goud H., Tang, Xuexi, Chen, Xiguang
Format: Article
Language:English
Subjects:
Chitosan
Controlled drug release
Drug release kinetics
Microspheres
Spray drying
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Summary:The aim of this article was to investigate the drug release kinetics of spray-dried chitosan microspheres using various kinetic models. The mean particle size and encapsulation efficiency of cross-linked chitosan microspheres was between 3.8 and 4.2 μm and 96.3 and 98.7%, respectively. Spray-dried chitosan microspheres were spherical in shape with smooth surface. The surface morphology of spray-dried chitosan microspheres was affected by the crystallinity of the loaded drug and cross-linking agent. The release data of the spray-dried chitosan microspheres were treated with zero-order, first-order, Higuchi, Korsmeyer, and Kopcha kinetic models and best fit was observed with Higuchi model, indicating the release of drug from spray-dried chitosan microspheres followed Fick's law of diffusion.
ISSN:0737-3937
1532-2300
DOI:10.1080/03602550600685325