Increase of Interstitial Collagen in the Mouse Endometrium During Decidualization

Decidualization in the mouse consists of an extensive remodeling of the endometrial extracellular matrix, resulting in a reduction of the extracellular spaces, an increase in the diameter of collagen fibrils, and changes in the relative ratio of different types of glycosaminoglycans. To assess the d...

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Bibliographic Details
Published in:Connective tissue research 2003, Vol.44 (2), p.96-103
Main Authors: Teodoro, W. R., Witzel, S. S., Velosa, A. P. P., Shimokomaki, M., Abrahamsohn, P. A., Zorn, T. M. T.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Collagen
Collagen - metabolism
Decidua - growth & development
Decidua - metabolism
Endometrium
Female
Hydroxyproline - metabolism
Mice
Mouse
Pregnancy
Time Factors
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Summary:Decidualization in the mouse consists of an extensive remodeling of the endometrial extracellular matrix, resulting in a reduction of the extracellular spaces, an increase in the diameter of collagen fibrils, and changes in the relative ratio of different types of glycosaminoglycans. To assess the dynamic changes of the endometrial extracellular matrix during decidualization, collagen was analyzed biochemically and immunochemically in the endometrium of nulliparous and day 5 to day 8 pregnant mice. The amount of collagen per gram dry weight was higher in the endometrium of implantation sites than in interimplantation sites. Collagen types I, III, and V were the main components of the endometrium of nulliparous and pregnant animals. The amount of collagen type V was higher in the endometrium of pregnant animals than in nulliparous ones. A relative unusual homotrimeric form of collagen type V, probably formed by [ &#102 1(V)] 3 , was detected in pregnant endometrium by gel eletrophoresis and immunoblotting.
ISSN:0300-8207
1607-8438
DOI:10.1080/03008200390200238