Development and validation of analytical methods for monomeric and oligomeric migrants from nylon 12 packaging materials

Analytical methods for the determination of laurolactam-the monomer of nylon 12-as well as the cyclic dimer and trimer were established. High performance liquid chromatography using ultraviolet (HPLC-UV) and mass spectrometric detection (HPLC-MS) were both found suitable to identify and quantify mon...

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Bibliographic Details
Published in:Food additives and contaminants 2003-04, Vol.20 (4), p.410-416
Main Authors: Stoffers, N. H., Brandl, F., Linssen, J. P. H., Franz, R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromatography, Gas - methods
Chromatography, High Pressure Liquid - methods
Food Contamination - analysis
Food industries
Food Packaging
Fundamental and applied biological sciences. Psychology
General aspects
Handling, storage, packaging, transport
Isomerism
Lactams - analysis
Laurolactam
microwave
Migration
Nylon 12
Nylons
Olive Oil
Plant Oils - chemistry
roasting bags
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Summary:Analytical methods for the determination of laurolactam-the monomer of nylon 12-as well as the cyclic dimer and trimer were established. High performance liquid chromatography using ultraviolet (HPLC-UV) and mass spectrometric detection (HPLC-MS) were both found suitable to identify and quantify monomer, cyclic dimer and trimer well below the specific migration limit (SML) of laurolactam, being 5 mg/kg of food (simulant). Gas chromatography with flame ionisation detection (GC-FID) showed to be an appropriate method for the detection of only laurolactam in aqueous and fatty food simulants. Food simulants could be analysed directly by all three methods, or after a change of solvents. For olive oil, a method for sample clean-up by size-exclusion chromatography (SEC) was established.
ISSN:0265-203X
1464-5122
DOI:10.1080/0265203031000087959