Green preparation, charetrization, in vitro/in vivo safety assessment and in vivo pain management of nortriptyline HCl loaded in niosome (norosome) manufactured by ecofriendly green method

Pain is an unfavorable feeling that is generally triggered by endogenous or exogenous harmful stimulation and has a strong emotional impact. The objective of this experimentation was to increase the cutaneous absorption of nortriptyline HCl (NOR) encapsulated in a niosome (norosomes) produced by an...

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Bibliographic Details
Published in:Journal of dispersion science and technology 2024-03, Vol.45 (4), p.819-831
Main Authors: Akbari, Jafar, Saeedi, Majid, Morteza-Semnani, Katayoun, Sanaee, Alireza, Lotfi, Amir, Rahimnia, Seyyed Mobin, Hashemi, Seyyed Mohammad Hassan, Omidi, Mahmoud
Format: Article
Language:English
Subjects:
Biocompatibility
Cholesterol
Dermal absorption
Entrapment
Green
In vivo methods and tests
Irritation
niosome
nortriptyline
Pain
Safety
Surface charge
Surfactants
transdermal
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Summary:Pain is an unfavorable feeling that is generally triggered by endogenous or exogenous harmful stimulation and has a strong emotional impact. The objective of this experimentation was to increase the cutaneous absorption of nortriptyline HCl (NOR) encapsulated in a niosome (norosomes) produced by an ultrasonic approach for the management of antinociceptive and anti-inflammatory disorders. Exploring the implications of the cholesterol:surfactant ratio on norosome compositions, the study revealed that increasing cholesterol significantly enlarged the norosome diameter from 66.84 ± 5.70 to 293.06 ± 36.54 nm (p 
ISSN:0193-2691
1532-2351
DOI:10.1080/01932691.2023.2289625