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S100B and Neuron-Specific Enolase as mortality predictors in patients with severe traumatic brain injury
Objective: To determine temporal profile and prognostic ability of S100B protein and neuron-specific enolase (NSE) for prediction of short/long-term mortality in patients suffering from severe traumatic brain injury (sTBI). Methods: Ninety-nine patients with sTBI were included in the study. Blood sa...
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| Published in: | Neurological research (New York) 2016-02, Vol.38 (2), p.130-137 |
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| container_issue | 2 |
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| container_title | Neurological research (New York) |
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| creator | Rodríguez-Rodríguez, Ana Egea-Guerrero, Juan José Gordillo-Escobar, Elena Enamorado-Enamorado, Judy Hernández-García, Conary Ruiz de Azúa-López, Zaida Vilches-Arenas, Ángel Guerrero, Juan Miguel Murillo-Cabezas, Francisco |
| description | Objective: To determine temporal profile and prognostic ability of S100B protein and neuron-specific enolase (NSE) for prediction of short/long-term mortality in patients suffering from severe traumatic brain injury (sTBI).
Methods: Ninety-nine patients with sTBI were included in the study. Blood samples were drawn on admission and on subsequent 24, 48, 72, and 96 h.
Results: 15.2% of patients died in NeuroCritical Care Unit, and 19.2% died within 6 months of the accident. S100B concentrations were significantly higher in patients who died compared to survivors. NSE levels were different between groups just at 48 h. In the survival group, S100B levels decreased from 1st to 5th sample (p |
| doi_str_mv | 10.1080/01616412.2016.1144410 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_01616412_2016_1144410</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1785214346</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-9d16c463996dded9e806f83fc2615fb4829b9ed90b8e9058606ce8ff5deb37de3</originalsourceid><addsrcrecordid>eNp9kMFO3DAQhi1UBMvCI7TysZcsdpw49q0tooCE4ACcLcceC6PETm0HtG_frHbpsacZzXwzv_Qh9JWSDSWCXBLKKW9ovamXbkNp0zSUHKEV7RpWUVaLL2i1Y6oddIrOcn4jhMpayBN0WnekE1zKFXp9ooT8wjpY_ABziqF6msB45w2-DnHQGbDOeIyp6MGXLZ4SWG9KTBn7gCddPISS8YcvrzjDOyTAJel5XBYG90kvkA9vc9qeo2OnhwwXh7pGL7-vn69uq_vHm7urn_eVYZyXSlrKTcOZlNxasBIE4U4wZ2pOW9c3opa9XOakFyBJKzjhBoRzrYWedRbYGn3f_51S_DNDLmr02cAw6ABxzop2oq1pw5aMNWr3qEkx5wROTcmPOm0VJWonWX1KVjvJ6iB5uft2iJj7Eey_q0-rC_BjD_jgYhr1R0yDVUVvh5hc0sH4rNj_M_4CldqMWw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1785214346</pqid></control><display><type>article</type><title>S100B and Neuron-Specific Enolase as mortality predictors in patients with severe traumatic brain injury</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><creator>Rodríguez-Rodríguez, Ana ; Egea-Guerrero, Juan José ; Gordillo-Escobar, Elena ; Enamorado-Enamorado, Judy ; Hernández-García, Conary ; Ruiz de Azúa-López, Zaida ; Vilches-Arenas, Ángel ; Guerrero, Juan Miguel ; Murillo-Cabezas, Francisco</creator><creatorcontrib>Rodríguez-Rodríguez, Ana ; Egea-Guerrero, Juan José ; Gordillo-Escobar, Elena ; Enamorado-Enamorado, Judy ; Hernández-García, Conary ; Ruiz de Azúa-López, Zaida ; Vilches-Arenas, Ángel ; Guerrero, Juan Miguel ; Murillo-Cabezas, Francisco</creatorcontrib><description>Objective: To determine temporal profile and prognostic ability of S100B protein and neuron-specific enolase (NSE) for prediction of short/long-term mortality in patients suffering from severe traumatic brain injury (sTBI).
Methods: Ninety-nine patients with sTBI were included in the study. Blood samples were drawn on admission and on subsequent 24, 48, 72, and 96 h.
Results: 15.2% of patients died in NeuroCritical Care Unit, and 19.2% died within 6 months of the accident. S100B concentrations were significantly higher in patients who died compared to survivors. NSE levels were different between groups just at 48 h. In the survival group, S100B levels decreased from 1st to 5th sample (p < 0.001); NSE just from 1st to 3rd (p < 0.001) and then stabilized. Values of S100B and NSE in non-survival patients did not significantly vary over the four days post sTBI. ROC-analysis showed that all S100B samples were useful tools for predicting mortality, the best the 72 h sample (AUC 0.848 for discharge mortality, 0.855 for six-month mortality). NSE ROC-analysis indicated that just the 48-h sample predicted mortality (AUC 0.733 for discharge mortality, 0.720 for six-month mortality).
Conclusion: S100B protein showed higher prognostic capacity than NSE to predict short/long-term mortality in sTBI patients.</description><identifier>ISSN: 0161-6412</identifier><identifier>EISSN: 1743-1328</identifier><identifier>DOI: 10.1080/01616412.2016.1144410</identifier><identifier>PMID: 27078699</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adult ; Biomarkers ; Brain Injuries, Traumatic - blood ; Brain Injuries, Traumatic - mortality ; Female ; Glasgow Coma Scale ; Humans ; Male ; Middle Aged ; Mortality ; Neuron-Specific Enolase ; Phosphopyruvate Hydratase - blood ; Predictive Value of Tests ; Retrospective Studies ; ROC Curve ; S100 Calcium Binding Protein beta Subunit - blood ; S100B ; Statistics, Nonparametric ; Time Factors ; Traumatic brain injury</subject><ispartof>Neurological research (New York), 2016-02, Vol.38 (2), p.130-137</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-9d16c463996dded9e806f83fc2615fb4829b9ed90b8e9058606ce8ff5deb37de3</citedby><cites>FETCH-LOGICAL-c366t-9d16c463996dded9e806f83fc2615fb4829b9ed90b8e9058606ce8ff5deb37de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27078699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodríguez-Rodríguez, Ana</creatorcontrib><creatorcontrib>Egea-Guerrero, Juan José</creatorcontrib><creatorcontrib>Gordillo-Escobar, Elena</creatorcontrib><creatorcontrib>Enamorado-Enamorado, Judy</creatorcontrib><creatorcontrib>Hernández-García, Conary</creatorcontrib><creatorcontrib>Ruiz de Azúa-López, Zaida</creatorcontrib><creatorcontrib>Vilches-Arenas, Ángel</creatorcontrib><creatorcontrib>Guerrero, Juan Miguel</creatorcontrib><creatorcontrib>Murillo-Cabezas, Francisco</creatorcontrib><title>S100B and Neuron-Specific Enolase as mortality predictors in patients with severe traumatic brain injury</title><title>Neurological research (New York)</title><addtitle>Neurol Res</addtitle><description>Objective: To determine temporal profile and prognostic ability of S100B protein and neuron-specific enolase (NSE) for prediction of short/long-term mortality in patients suffering from severe traumatic brain injury (sTBI).
Methods: Ninety-nine patients with sTBI were included in the study. Blood samples were drawn on admission and on subsequent 24, 48, 72, and 96 h.
Results: 15.2% of patients died in NeuroCritical Care Unit, and 19.2% died within 6 months of the accident. S100B concentrations were significantly higher in patients who died compared to survivors. NSE levels were different between groups just at 48 h. In the survival group, S100B levels decreased from 1st to 5th sample (p < 0.001); NSE just from 1st to 3rd (p < 0.001) and then stabilized. Values of S100B and NSE in non-survival patients did not significantly vary over the four days post sTBI. ROC-analysis showed that all S100B samples were useful tools for predicting mortality, the best the 72 h sample (AUC 0.848 for discharge mortality, 0.855 for six-month mortality). NSE ROC-analysis indicated that just the 48-h sample predicted mortality (AUC 0.733 for discharge mortality, 0.720 for six-month mortality).
Conclusion: S100B protein showed higher prognostic capacity than NSE to predict short/long-term mortality in sTBI patients.</description><subject>Adult</subject><subject>Biomarkers</subject><subject>Brain Injuries, Traumatic - blood</subject><subject>Brain Injuries, Traumatic - mortality</subject><subject>Female</subject><subject>Glasgow Coma Scale</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neuron-Specific Enolase</subject><subject>Phosphopyruvate Hydratase - blood</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>S100 Calcium Binding Protein beta Subunit - blood</subject><subject>S100B</subject><subject>Statistics, Nonparametric</subject><subject>Time Factors</subject><subject>Traumatic brain injury</subject><issn>0161-6412</issn><issn>1743-1328</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kMFO3DAQhi1UBMvCI7TysZcsdpw49q0tooCE4ACcLcceC6PETm0HtG_frHbpsacZzXwzv_Qh9JWSDSWCXBLKKW9ovamXbkNp0zSUHKEV7RpWUVaLL2i1Y6oddIrOcn4jhMpayBN0WnekE1zKFXp9ooT8wjpY_ABziqF6msB45w2-DnHQGbDOeIyp6MGXLZ4SWG9KTBn7gCddPISS8YcvrzjDOyTAJel5XBYG90kvkA9vc9qeo2OnhwwXh7pGL7-vn69uq_vHm7urn_eVYZyXSlrKTcOZlNxasBIE4U4wZ2pOW9c3opa9XOakFyBJKzjhBoRzrYWedRbYGn3f_51S_DNDLmr02cAw6ABxzop2oq1pw5aMNWr3qEkx5wROTcmPOm0VJWonWX1KVjvJ6iB5uft2iJj7Eey_q0-rC_BjD_jgYhr1R0yDVUVvh5hc0sH4rNj_M_4CldqMWw</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Rodríguez-Rodríguez, Ana</creator><creator>Egea-Guerrero, Juan José</creator><creator>Gordillo-Escobar, Elena</creator><creator>Enamorado-Enamorado, Judy</creator><creator>Hernández-García, Conary</creator><creator>Ruiz de Azúa-López, Zaida</creator><creator>Vilches-Arenas, Ángel</creator><creator>Guerrero, Juan Miguel</creator><creator>Murillo-Cabezas, Francisco</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>S100B and Neuron-Specific Enolase as mortality predictors in patients with severe traumatic brain injury</title><author>Rodríguez-Rodríguez, Ana ; Egea-Guerrero, Juan José ; Gordillo-Escobar, Elena ; Enamorado-Enamorado, Judy ; Hernández-García, Conary ; Ruiz de Azúa-López, Zaida ; Vilches-Arenas, Ángel ; Guerrero, Juan Miguel ; Murillo-Cabezas, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-9d16c463996dded9e806f83fc2615fb4829b9ed90b8e9058606ce8ff5deb37de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Biomarkers</topic><topic>Brain Injuries, Traumatic - blood</topic><topic>Brain Injuries, Traumatic - mortality</topic><topic>Female</topic><topic>Glasgow Coma Scale</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neuron-Specific Enolase</topic><topic>Phosphopyruvate Hydratase - blood</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>S100 Calcium Binding Protein beta Subunit - blood</topic><topic>S100B</topic><topic>Statistics, Nonparametric</topic><topic>Time Factors</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez-Rodríguez, Ana</creatorcontrib><creatorcontrib>Egea-Guerrero, Juan José</creatorcontrib><creatorcontrib>Gordillo-Escobar, Elena</creatorcontrib><creatorcontrib>Enamorado-Enamorado, Judy</creatorcontrib><creatorcontrib>Hernández-García, Conary</creatorcontrib><creatorcontrib>Ruiz de Azúa-López, Zaida</creatorcontrib><creatorcontrib>Vilches-Arenas, Ángel</creatorcontrib><creatorcontrib>Guerrero, Juan Miguel</creatorcontrib><creatorcontrib>Murillo-Cabezas, Francisco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological research (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodríguez-Rodríguez, Ana</au><au>Egea-Guerrero, Juan José</au><au>Gordillo-Escobar, Elena</au><au>Enamorado-Enamorado, Judy</au><au>Hernández-García, Conary</au><au>Ruiz de Azúa-López, Zaida</au><au>Vilches-Arenas, Ángel</au><au>Guerrero, Juan Miguel</au><au>Murillo-Cabezas, Francisco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>S100B and Neuron-Specific Enolase as mortality predictors in patients with severe traumatic brain injury</atitle><jtitle>Neurological research (New York)</jtitle><addtitle>Neurol Res</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>38</volume><issue>2</issue><spage>130</spage><epage>137</epage><pages>130-137</pages><issn>0161-6412</issn><eissn>1743-1328</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objective: To determine temporal profile and prognostic ability of S100B protein and neuron-specific enolase (NSE) for prediction of short/long-term mortality in patients suffering from severe traumatic brain injury (sTBI).
Methods: Ninety-nine patients with sTBI were included in the study. Blood samples were drawn on admission and on subsequent 24, 48, 72, and 96 h.
Results: 15.2% of patients died in NeuroCritical Care Unit, and 19.2% died within 6 months of the accident. S100B concentrations were significantly higher in patients who died compared to survivors. NSE levels were different between groups just at 48 h. In the survival group, S100B levels decreased from 1st to 5th sample (p < 0.001); NSE just from 1st to 3rd (p < 0.001) and then stabilized. Values of S100B and NSE in non-survival patients did not significantly vary over the four days post sTBI. ROC-analysis showed that all S100B samples were useful tools for predicting mortality, the best the 72 h sample (AUC 0.848 for discharge mortality, 0.855 for six-month mortality). NSE ROC-analysis indicated that just the 48-h sample predicted mortality (AUC 0.733 for discharge mortality, 0.720 for six-month mortality).
Conclusion: S100B protein showed higher prognostic capacity than NSE to predict short/long-term mortality in sTBI patients.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>27078699</pmid><doi>10.1080/01616412.2016.1144410</doi><tpages>8</tpages></addata></record> |
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| ispartof | Neurological research (New York), 2016-02, Vol.38 (2), p.130-137 |
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| language | eng |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adult Biomarkers Brain Injuries, Traumatic - blood Brain Injuries, Traumatic - mortality Female Glasgow Coma Scale Humans Male Middle Aged Mortality Neuron-Specific Enolase Phosphopyruvate Hydratase - blood Predictive Value of Tests Retrospective Studies ROC Curve S100 Calcium Binding Protein beta Subunit - blood S100B Statistics, Nonparametric Time Factors Traumatic brain injury |
| title | S100B and Neuron-Specific Enolase as mortality predictors in patients with severe traumatic brain injury |
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