S100B and Neuron-Specific Enolase as mortality predictors in patients with severe traumatic brain injury

Objective: To determine temporal profile and prognostic ability of S100B protein and neuron-specific enolase (NSE) for prediction of short/long-term mortality in patients suffering from severe traumatic brain injury (sTBI). Methods: Ninety-nine patients with sTBI were included in the study. Blood sa...

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Bibliographic Details
Published in:Neurological research (New York) 2016-02, Vol.38 (2), p.130-137
Main Authors: Rodríguez-Rodríguez, Ana, Egea-Guerrero, Juan José, Gordillo-Escobar, Elena, Enamorado-Enamorado, Judy, Hernández-García, Conary, Ruiz de Azúa-López, Zaida, Vilches-Arenas, Ángel, Guerrero, Juan Miguel, Murillo-Cabezas, Francisco
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Brain Injuries, Traumatic - blood
Brain Injuries, Traumatic - mortality
Female
Glasgow Coma Scale
Humans
Male
Middle Aged
Mortality
Neuron-Specific Enolase
Phosphopyruvate Hydratase - blood
Predictive Value of Tests
Retrospective Studies
ROC Curve
S100 Calcium Binding Protein beta Subunit - blood
S100B
Statistics, Nonparametric
Time Factors
Traumatic brain injury
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Summary:Objective: To determine temporal profile and prognostic ability of S100B protein and neuron-specific enolase (NSE) for prediction of short/long-term mortality in patients suffering from severe traumatic brain injury (sTBI). Methods: Ninety-nine patients with sTBI were included in the study. Blood samples were drawn on admission and on subsequent 24, 48, 72, and 96 h. Results: 15.2% of patients died in NeuroCritical Care Unit, and 19.2% died within 6 months of the accident. S100B concentrations were significantly higher in patients who died compared to survivors. NSE levels were different between groups just at 48 h. In the survival group, S100B levels decreased from 1st to 5th sample (p 
ISSN:0161-6412
1743-1328
DOI:10.1080/01616412.2016.1144410