Two coordination polymers: effect on the learning and memory impairment in epilepsy mice by regulating the mTOR signaling pathway

Under similar hydrothermal conditions, via using the mixed-ligand method, two 3-D coordination polymers (CPs) [Zn(HIPA)(bmimb)] n (1, bmimb = 1,4-bis(2-methyl-1H-imidazol-1-yl)benzene)) and [Cu 2 (HIPA) 2 (bmib) 3 ] n (2, bmib = 1,4-bis(1H-imidazol-1-yl)benzene) were fabricated based on the reaction...

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Bibliographic Details
Published in:Journal of coordination chemistry 2020-11, Vol.73 (24), p.3354-3362
Main Authors: Guo, Zhen-Wei, Zhang, Guang-Hui, He, Ming-Li, He, Xiao-Bing, Lv, Hong, Yang, Xiufeng
Format: Article
Language:English
Subjects:
Benzene
Coordination polymers
crystal structures
Epilepsy
epilepsy mice
Hydrocarbons
Impairment
Learning
Ligands
Memory
Signaling
western blot
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Summary:Under similar hydrothermal conditions, via using the mixed-ligand method, two 3-D coordination polymers (CPs) [Zn(HIPA)(bmimb)] n (1, bmimb = 1,4-bis(2-methyl-1H-imidazol-1-yl)benzene)) and [Cu 2 (HIPA) 2 (bmib) 3 ] n (2, bmib = 1,4-bis(1H-imidazol-1-yl)benzene) were fabricated based on the reaction of Zn(NO 3 ) 2 ·6H 2 O or Cu(NO 3 ) 2 ·3H 2 O with 5-(hydroxymethyl)isophthalic acid (H 3 IPA) when N-donor co-ligands were present. The compounds were evaluated to improve the learning and memory impairment in epilepsy mice and the relationship between the mTOR signaling pathway and epilepsy is discussed. To determine the influence of 1 and 2 on epilepsy mice cognitive function, the Morris Water Maze Test was performed. The mTOR signaling pathway expression levels were then detected with western blot.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2020.1849640