Polymorphisms in xenobiotic metabolism-related genes in patients with hepatocellular carcinoma: a case-control study

This study was performed to investigate the relationship between polymorphisms in microsomal epoxide hydrolase (mEH; Tyr113His and His139Arg substitution) and glutathione S-transferase (GST; GSTM1 deletion, GSTT1 deletion, and GSTP1.Ala114Val substitution) and their correlation with clinico-histopat...

Full description

Saved in:
Bibliographic Details
Published in:Xenobiotica 2021-06, Vol.51 (6), p.737-744
Main Authors: Ferreira, Gislaine Dionísio, Fernandes, Glaucia Maria de Mendonça, Penteado, Camila, Cória, Vivian Romanholi, Galbiatti-Dias, Ana Lívia da Silva, Russo, Anelise, Castanhole-Nunes, Márcia Maria Urbanin, Silva, Renato Ferreira da, Silva, Rita de Cássia Martins Alves da, Pavarino, Érika Cristina, Torreglosa Ruiz Cintra, Mariangela, Goloni-Bertollo, Eny Maria
Format: Article
Language:English
Subjects:
epoxide hydrolase
glutathione S-transferase
hepatocellular carcinoma
Single-nucleotide polymorphism
xenobiotic metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study was performed to investigate the relationship between polymorphisms in microsomal epoxide hydrolase (mEH; Tyr113His and His139Arg substitution) and glutathione S-transferase (GST; GSTM1 deletion, GSTT1 deletion, and GSTP1.Ala114Val substitution) and their correlation with clinico-histopathological features in hepatocellular carcinoma (HCC). We evaluated environmental risk factors and genetic alterations in 556 individuals (86 cases and 470 controls). PCR multiplex for GSTM1 and GSTT1, polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) for GSTP1, and real-time PCR for mEH were performed. Statistical analyses were performed using multiple logistic regression tests. Age over 48 years (p 
ISSN:0049-8254
1366-5928
DOI:10.1080/00498254.2021.1893408