An Efficient General Synthesis of Squarate Esters

An efficient and general method for the synthesis of alkyl squarates is presented. This involves the reactions of squaric acid with the desired alcohol in the presence of an orthoformate. This was applicable for the synthesis of dimethyl-, diethyl-, diisopropyl, di-n-butyl and di-t-butyl squarates i...

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Bibliographic Details
Published in:Synthetic communications 1997-06, Vol.27 (12), p.2177-2180
Main Authors: Liu, Hiu, Tomooka, Craig S., Moore, Harold W.
Format: Article
Language:English
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Summary:An efficient and general method for the synthesis of alkyl squarates is presented. This involves the reactions of squaric acid with the desired alcohol in the presence of an orthoformate. This was applicable for the synthesis of dimethyl-, diethyl-, diisopropyl, di-n-butyl and di-t-butyl squarates in yields ranging from 77-97%. It is a convenient and safe method that can be accomplished on a multigram scale.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919708006826