Systemic inflammation and dyslipidemia are associated with retinopathy in type 2 but not in type 1 diabetes

The aim of this study was to investigate risk factors and role of systemic inflammation, dyslipidemia and obesity in development of diabetic retinopathy (DR) in type 1 and type 2 diabetes and determine the differences in risk factors between these two types of diabetes. Eighty-four type 1 and 107 ty...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 2020-10, Vol.80 (6), p.484-490
Main Authors: Tomić, Martina, Vrabec, Romano, Vidas Pauk, Sania, Bulum, Tomislav, Ljubić, Spomenka
Format: Article
Language:English
Subjects:
dyslipidemia
obesity
retinopathy
risk factors
systemic inflammation
Type 1 and type 2 diabetes
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Summary:The aim of this study was to investigate risk factors and role of systemic inflammation, dyslipidemia and obesity in development of diabetic retinopathy (DR) in type 1 and type 2 diabetes and determine the differences in risk factors between these two types of diabetes. Eighty-four type 1 and 107 type 2 diabetic patients were included in this cross-sectional study. Diabetes duration, body mass index (BMI) and waist-to-hip ratio (WHR) were assessed. C-reactive protein (CRP), fibrinogen (FIB), glycated hemoglobin (HbA 1 c), fasting and postprandial blood glucose (fBG, ppBG), HDL and LDL cholesterol and triglycerides (TG) were determined using routine methods. HbA 1 c median was obtained by statistical analysis of the CroDiabNet data and used as a marker of long-term glycemic control. Albumin excretion rate (AER) was measured in a 24-hour urine collection. Ophthalmologic retinal examination included indirect slit-lamp fundoscopy, color fundus photography according to EURODIAB (EUROpe and DIABetes) protocol and optical coherence tomography. DR was positively related to diabetes duration (p 
ISSN:0036-5513
1502-7686
DOI:10.1080/00365513.2020.1789921