Type 2 diabetes mellitus is associated with differential effects on plasma cholesteryl ester transfer protein and phospholipid transfer protein activities and concentrations

Background: Human plasma contains two lipid transfer proteins, cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP), which are crucial in reverse cholesterol transport. Methods: Plasma CETP and PLTP activity levels and concentrations in 16 type 2 diabetic patients and 1...

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Published in:Scandinavian journal of clinical and laboratory investigation 2004-06, Vol.64 (3), p.205-216
Main Authors: Dullaart, R. P. F., Vries, R. De, Scheek, L., Borggreve, S. E., Gent, T. Van, Dallinga-Thie, G. M., Ito, M., Nagano, M., Sluiter, W. J., Hattori, H., Tol, A. Van
Format: Article
Language:English
Subjects:
Apolipoproteins - blood
Blood Glucose - analysis
Body Composition
Body Mass Index
Carrier Proteins - blood
Cholesterol - blood
Cholesterol Ester Transfer Proteins
Cholesteryl ester transfer protein
Diabetes Mellitus, Type 2 - blood
Glucose Clamp Technique
Glycated Hemoglobin A - analysis
glycation
Glycoproteins - blood
high-density lipoproteins
Humans
Insulin - blood
Lipoproteins - blood
Membrane Proteins - blood
Middle Aged
phospholipid transfer protein
Phospholipid Transfer Proteins - blood
Regression Analysis
reverse cholesterol transport
Statistics, Nonparametric
Triglycerides - blood
type 2 diabetes mellitus
Waist-Hip Ratio
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Summary:Background: Human plasma contains two lipid transfer proteins, cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP), which are crucial in reverse cholesterol transport. Methods: Plasma CETP and PLTP activity levels and concentrations in 16 type 2 diabetic patients and 16 matched healthy subjects were determined, and these data were correlated to clinical variables, including insulin sensitivity and lipid levels. Results: Plasma triglycerides were higher (p
ISSN:0036-5513
1502-7686
DOI:10.1080/00365510410005721