Amygdala lesions disrupt modulation of functional MRI activity evoked by facial expression in the monkey inferior temporal cortex

Significance Successful social interaction depends on the ability to recognize others, evaluate their mental states (e.g. intentions, desires, and beliefs), and “read” their emotional states. Here, we show that, in monkeys, damage to the amygdala, a brain structure that is central to the expression...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2012-12, Vol.109 (52), p.E3640-E3648
Main Authors: Hadj-Bouziane, Fadila, Liu, Ning, Bell, Andrew H, Gothard, Katalin M, Luh, Wen-Ming, Tootell, Roger B H, Murray, Elisabeth A, Ungerleider, Leslie G
Format: Article
Language:English
Subjects:
Amygdala - pathology
Amygdala - physiopathology
Animal behavior
Animal cognition
Animals
Biological Sciences
Brain
Brain Mapping
Evoked Potentials - physiology
Facial Expression
Life Sciences
Macaca mulatta - physiology
Magnetic Resonance Imaging
Male
Monkeys & apes
NMR
Nuclear magnetic resonance
PNAS Plus
Temporal Lobe - physiopathology
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Summary:Significance Successful social interaction depends on the ability to recognize others, evaluate their mental states (e.g. intentions, desires, and beliefs), and “read” their emotional states. Here, we show that, in monkeys, damage to the amygdala, a brain structure that is central to the expression of emotion, significantly disrupts the processing of emotional facial expression in high-level visual cortical areas involved in face recognition. These findings suggest that the projections of the amygdala to visual cortical areas likely enhance the sensory processing of biologically important signals, including those related to potential environmental threats and social contexts.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1218406109