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Synthetic nucleases triggered by mild acidification: a new type of biologically active compounds

Alkylcobalt chelates possessing tridentate Schiff bases display nuclease activity upon proton-assisted homolytic decomposition, due to the formation of both alkyl free radicals and a cobalt complex catalysing the autooxidation of organic substrates.

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Bibliographic Details
Published in:Mendeleev communications 1996, Vol.6 (4), p.153-154
Main Authors: Levitin, Ilia Ya, Belkov, Vladimir M., Novodarova, Galina N., Shabarova, Zoya A., Vol’pin, Mark E.
Format: Article
Language:English
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Summary:Alkylcobalt chelates possessing tridentate Schiff bases display nuclease activity upon proton-assisted homolytic decomposition, due to the formation of both alkyl free radicals and a cobalt complex catalysing the autooxidation of organic substrates.
ISSN:0959-9436
DOI:10.1070/MC1996v006n04ABEH000624