Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: Results from the NHLBI WISE study

Background Chest pain in the absence of obstructive coronary artery disease (CAD) is common in women; it is frequently associated with debilitating symptoms and repeated evaluations and may be caused by coronary microvascular dysfunction. However, the prevalence and determinants of microvascular dys...

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Bibliographic Details
Published in:The American heart journal 2001-05, Vol.141 (5), p.735-741
Main Authors: Reis, Steven E., Holubkov, Richard, Smith, A.J.Conrad, Kelsey, Sheryl F., Sharaf, Barry L., Reichek, Nathaniel, Rogers, William J., Merz, C.Noel Bairey, Sopko, George, Pepine, Carl J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Flow Velocity
Cardiac Catheterization
Cardiology. Vascular system
Cardiotonic Agents
Chest Pain - blood
Chest Pain - diagnosis
Chest Pain - epidemiology
Chest Pain - physiopathology
Cholesterol - blood
Coronary Angiography
Coronary Artery Disease - diagnosis
Coronary Artery Disease - etiology
Coronary Circulation
Coronary heart disease
Coronary Vessels - physiopathology
Diagnosis, Differential
Dobutamine
Echocardiography
Female
Gonadal Steroid Hormones - blood
Heart
Hormone Replacement Therapy - adverse effects
Humans
Medical sciences
Microcirculation - physiopathology
Postmenopause - blood
Prevalence
Risk Factors
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Summary:Background Chest pain in the absence of obstructive coronary artery disease (CAD) is common in women; it is frequently associated with debilitating symptoms and repeated evaluations and may be caused by coronary microvascular dysfunction. However, the prevalence and determinants of microvascular dysfunction in these women are uncertain. Methods We measured coronary flow velocity reserve (coronary velocity response to intracoronary adenosine) to evaluate the coronary microvasculature and risk factors for atherosclerosis in 159 women (mean age, 52.9 years) with chest pain and no obstructive CAD. All women were referred for coronary angiography to evaluate their chest pain as part of the Women’s Ischemia Syndrome Evaluation (WISE) study. Results Seventy-four (47%) women had subnormal (
ISSN:0002-8703
1097-6744
DOI:10.1067/mhj.2001.114198