Design and validation of microfluidic parameters of a microfluidic chip using fluid dynamics

The internal fluidic parameters of microfluidic channels must be analyzed to solve fundamental microfluidic problems, including microscale transport problems involving thermal analysis, chemical reactivity, velocity, pressure drop, etc., for developing good-quality chemical and biological products....

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Bibliographic Details
Published in:AIP advances 2021-07, Vol.11 (7), p.075224-075224-9
Main Authors: Ahmed, Feroz, Yoshida, Yuichi, Wang, Jin, Sakai, Kenji, Kiwa, Toshihiko
Format: Article
Language:English
Subjects:
Buffer solutions
CAD
Channels
Computational fluid dynamics
Computer aided design
Data analysis
Design
Fluid dynamics
Fluid flow
Microfluidics
Optimization
Parameters
Polydimethylsiloxane
Pressure drop
Quality assurance
Simulation
Software
Thermal analysis
Velocity distribution
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Summary:The internal fluidic parameters of microfluidic channels must be analyzed to solve fundamental microfluidic problems, including microscale transport problems involving thermal analysis, chemical reactivity, velocity, pressure drop, etc., for developing good-quality chemical and biological products. Therefore, the characterization and optimization of the interaction of chemical and biological solutions through microfluidic channels are vital for fluid flow design and engineering for quality assurance in microfluidic platforms. As the internal structures and kinetics of microfluidic channels are becoming increasingly complex, experiments involving optimal fluidic and transport designs are challenging to perform with high accuracy. However, highly integrated simulation tools can guide researchers without specialized computational fluid backgrounds to design numerical prototypes of highly integrated devices. In this study, a microfluidic chip with two inlet wells and one outlet well was fabricated from polydimethylsiloxane following which simulations were performed using an ANSYS Fluent tool influenced by computational fluid dynamics at a nearly identical scale. The pressure drop and velocity profiles of the interaction of two pH buffer solutions (pH 4 and 10) through the designed microfluidic chip were qualitatively estimated from experimental data analysis and validated with the simulation results obtained from the CFD-influenced ANSYS Fluent tool.
ISSN:2158-3226
2158-3226
DOI:10.1063/5.0056597