Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening

A combined optical coherence tomography (OCT)-Raman probe was designed and built into a spectral domain OCT head, and its performance was evaluated and compared to the most common Raman probe setups, based on a fiber bundle and confocal free space optics. Due to the use of the full field of view of...

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Bibliographic Details
Published in:Review of scientific instruments 2017-10, Vol.88 (10), p.105103-105103
Main Authors: Mazurenka, M., Behrendt, L., Meinhardt-Wollweber, M., Morgner, U., Roth, B.
Format: Article
Language:English
Subjects:
Cancer
Early Detection of Cancer
Exposure limits
Field of view
Free space optics
Humans
Medical screening
Melanoma - diagnostic imaging
Melanoma, Cutaneous Malignant
Optical Coherence Tomography
Raman spectra
Scientific apparatus & instruments
Skin cancer
Skin Neoplasms - diagnostic imaging
Tomography, Optical Coherence
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Summary:A combined optical coherence tomography (OCT)-Raman probe was designed and built into a spectral domain OCT head, and its performance was evaluated and compared to the most common Raman probe setups, based on a fiber bundle and confocal free space optics. Due to the use of the full field of view of an OCT scanning lens, the combined probe has a superior performance within maximum permissible exposure limits, compared to the other two probes. Skin Raman spectra, recorded in vivo, further prove the feasibility of the OCT-Raman probe for the future in vivo clinical applications in skin cancer screening.
ISSN:0034-6748
1089-7623
DOI:10.1063/1.5004999