Synthesis of 1,3-Disubstituted N-Amino-1,2,3,4-tetrahydroisoquinolines

Abstract The synthesis of 1,3-disubstituted N-amino-1,2,3,4-tetrahydroisoquinolines from the corresponding hydrazide intermediate via Pictet-Spengler reaction is described and the effect of the aldehyde on the stereoconfiguration of the products is discussed.

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Bibliographic Details
Published in:Synlett 2007-02, Vol.2007 (3), p.0374-0380
Main Authors: Zhang, Li, Zheng, Xiu-Fang, Linn, Gregory, Zhao, Kang
Format: Article
Language:English
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Summary:Abstract The synthesis of 1,3-disubstituted N-amino-1,2,3,4-tetrahydroisoquinolines from the corresponding hydrazide intermediate via Pictet-Spengler reaction is described and the effect of the aldehyde on the stereoconfiguration of the products is discussed.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2007-967948