Radical Addition/Cyclization Cascade: An Efficient Approach to Nitro-Containing Quinoline-2,4(1H,3H)-diones

Abstract A radical addition/cyclization cascade of o -cyanoarylacrylamides with magnesium nitrate hexahydrate is developed. This reaction exhibits good functional group tolerance and wide substrate scope, provides a highly efficient and practical access to nitro-containing quinoline-2,4(1 H ,3 H )-d...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2018-09, Vol.50 (17), p.3460-3466
Main Authors: Yang, Tao, Zhou, Jia-Li, Li, Junpeng, Shen, Yuehai, Gao, Chuanzhu, Li, Ya-Min
Format: Article
Language:English
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Summary:Abstract A radical addition/cyclization cascade of o -cyanoarylacrylamides with magnesium nitrate hexahydrate is developed. This reaction exhibits good functional group tolerance and wide substrate scope, provides a highly efficient and practical access to nitro-containing quinoline-2,4(1 H ,3 H )-diones.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0037-1610070