tert-Butyl Peroxybenzoate Mediated Selective and Mild N-Benzoylation of Ammonia/Amines under Catalyst- and Solvent-Free Conditions

Abstract A new protocol for the synthesis of amides from tert -butyl peroxybenzoate (TBPB) and ammonia/amines has been developed under catalyst- and solvent-free conditions. The ammonia, primary and secondary amines reacted smoothly with TBPB to furnish the corresponding primary, secondary, and tert...

Full description

Saved in:
Bibliographic Details
Published in:Synlett 2015-08, Vol.26 (13), p.1862-1866
Main Authors: Yadav, Dilip Kumar T., Bhanage, Bhalchandra M.
Format: Article
Language:English
Subjects:
letter
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract A new protocol for the synthesis of amides from tert -butyl peroxybenzoate (TBPB) and ammonia/amines has been developed under catalyst- and solvent-free conditions. The ammonia, primary and secondary amines reacted smoothly with TBPB to furnish the corresponding primary, secondary, and tertiary amides in excellent yields. TBPB proved to be an efficient and highly chemoselective benzoylating reagent for aliphatic amines in the presence of aromatic amines/ ­hydroxyl groups.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0034-1380811