Efficient Synthesis of 4-Amino-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5-ones: Practical Access to a Novel Chemotype in the Development of DGAT-1 Inhibitors

Abstract A practical access to an unprecedented, fused bicyclic 4-amino-2-alkoxy-7,8-dihydropyrido[4,3- d ]pyrimidin-5-one scaffold is developed. The synthesis of the potent inhibitor, 2-{4-[4-amino-2-methoxy-5-oxo-7,8-dihydropyrido[4,3- d ]pyrimidin-6(5 H )-yl]phenyl}-2-methylpropanamide is detaile...

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Published in:	Synthesis (Stuttgart) 2012-10, Vol.44 (20), p.3152-3157
Main Authors:	Bahnck, Kevin B., Shavnya, Andrei, Tao, Yong, Lilley, Susan C., Andrews, Melissa P., Aspnes, Gary E., Bernhardson, David J., Bill, David R., Bundesmann, Mark W., Dow, Robert L., Karki, Kapil, Le, Tung, Li, Qifang, Munchhof, Michael J., Nematalla, Asaad, Nihlawi, Mohammed, Patel, Leena, Perreault, Christian, Waldo, Michael
Format:	Article
Language:	English
Subjects:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Organic chemistry practical synthetic procedures Preparations and properties
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