Total Synthesis of (+)-Brefeldin C Utilizing Aza-Claisen Rearrangement

Abstract The total synthesis of (+)-brefeldin C was accomplished. An asymmetric aza-Claisen rearrangement developed by our laboratory was employed to construct the C-4 and C-5 stereogenic centers of (+)-brefeldin C as a key step.

Bibliographic Details

Published in:	Synlett 2011-06, Vol.2011 (10), p.1459-1461
Main Authors:	Inai, Makoto, Nishii, Takeshi, Mukoujima, Shingo, Esumi, Tomoyuki, Kaku, Hiroto, Tominaga, Keiko, Abe, Hiroaki, Horikawa, Mitsuyo, Tsunoda, Tetsuto
Format:	Article
Language:	English
Subjects:	Alicyclic compounds Alicyclic compounds, terpenoids, prostaglandins, steroids Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives letter Organic chemistry Preparations and properties
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