New Types of o-Carborane-Based Chiral Phosphinooxazoline (Cab-PHOX) Ligand Systems: Synthesis and Characterization of Chiral Cab-PHOX Ligands and Their Application to Asymmetric Hydrogenation

Abstract O-Carborane-based chiral phosphinooxazoline (Cab-PHOX) ligands were synthesized for the first time and applied to the iridium- and rhodium-catalyzed hydrogenation of unfunctionalized and functionalized olefins with an enantioselectivity of up to 98% and 96%, respectively. The modularity of...

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Bibliographic Details
Published in:Synlett 2009-03, Vol.2009 (5), p.771-774
Main Authors: Lee, Jong-Dae, Co, Thanh Thien, Kim, Tae-Jeong, Kang, Sang Ook
Format: Article
Language:English
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Summary:Abstract O-Carborane-based chiral phosphinooxazoline (Cab-PHOX) ligands were synthesized for the first time and applied to the iridium- and rhodium-catalyzed hydrogenation of unfunctionalized and functionalized olefins with an enantioselectivity of up to 98% and 96%, respectively. The modularity of the Cab-PHOX ligands is highlighted by the facile preparation of a variety of sterically and electronically different ligands.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0028-1087934