Fatty acid ethyl esters: recent observations

Fatty acid ethyl esters (FAEE), esterification products of fatty acids and ethanol, have been shown to be mediators of ethanol-induced cell injury and their presence in the blood and tissues is a marker of ethanol intake. Recently, it has been shown that FAEE are produced within seconds of infusion...

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Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2002-08, Vol.67 (2), p.193-196
Main Authors: Laposata, Michael, Hasaba, Ali, Best, Catherine A., Yoerger, Danita M., McQuillan, Brendan M., Salem, Raneem O., Refaai, Majed A., Soderberg, Britt L.
Format: Article
Language:English
Subjects:
Alcoholism - diagnosis
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Biomarkers - analysis
Biomarkers - blood
Esterification
Esters - blood
Esters - isolation & purification
Esters - metabolism
Ethanol - pharmacology
Fatty Acids - blood
Fatty Acids - isolation & purification
Fatty Acids - metabolism
Humans
Medical sciences
Toxicology
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Summary:Fatty acid ethyl esters (FAEE), esterification products of fatty acids and ethanol, have been shown to be mediators of ethanol-induced cell injury and their presence in the blood and tissues is a marker of ethanol intake. Recently, it has been shown that FAEE are produced within seconds of infusion of ethanol into the heart, when using a protocol similar to that used for myocardial ablation. This raises the possibility that the mechanism for the death of myocytes in cardiac ablation involves the generation of toxic FAEE. It has also been recently demonstrated that chronic alcoholics have a high concentration of a specific FAEE species—ethyl oleate. The use of the serum ethyl oleate concentration may be helpful in differentiating binge drinkers from chronic alcoholics.
ISSN:0952-3278
1532-2823
DOI:10.1054/plef.2002.0418