Polymer physics, scaling and heterogeneity in the spatial organisation of chromosomes in the cell nucleus

We review some of the recent progresses made by the application of polymer physics to the understanding of the spatial organization of chromosomes in the cell nucleus. In particular, we focus on some scaling properties of the contact probability of pairs of sites, discovered by recent genome-wide ex...

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Bibliographic Details
Published in:Soft matter 2013-01, Vol.9 (36), p.8631-8635
Main Authors: Barbieri, M, Scialdone, A, Gamba, A, Pombo, A, Nicodemi, M
Format: Article
Language:English
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Summary:We review some of the recent progresses made by the application of polymer physics to the understanding of the spatial organization of chromosomes in the cell nucleus. In particular, we focus on some scaling properties of the contact probability of pairs of sites, discovered by recent genome-wide experiments exploiting new technologies such as Hi-C methods. We review some of the recent progresses made by the application of polymer physics to the understanding of the spatial organization of chromosomes in the cell nucleus.
ISSN:1744-683X
1744-6848
DOI:10.1039/c3sm51436f