Fe3O4-silica core-shell nanoporous particles for high-capacity pH-triggered drug delivery

We demonstrate a one-step procedure for the synthesis of Fe 3 O 4 -silica core-shell nanoparticles with hierarchically ultra-large pores independent of any post-treatment such as annealing and template-molecule removal. The nanoporous silica shells with available amine groups were functionalized by...

Full description

Saved in:
Bibliographic Details
Published in:Journal of materials chemistry 2012-01, Vol.22 (29), p.1445-14457
Main Authors: Zhang, X. F, Mansouri, S, Clime, L, Ly, H. Q, Yahia, L. 'H, Veres, T
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We demonstrate a one-step procedure for the synthesis of Fe 3 O 4 -silica core-shell nanoparticles with hierarchically ultra-large pores independent of any post-treatment such as annealing and template-molecule removal. The nanoporous silica shells with available amine groups were functionalized by clickable linkers to produce pH-sensitive amides for regulating the release of an anti-cancer drug, doxorubicin (DOX). The loading amount of DOX reached up to 13.2 mg per 100 mg nanoparticles, 74.2% of which can be effectively released after 63 h at body temperature and pH 5 with decreased side effects. Such excellent features of these nanoparticles appear to arise from the integrated hierarchically ultra-large open-porosities and a homogeneous dispersibility in aqueous solution that has a great potential for their use as drug delivery systems. We demonstrate a one-step procedure for the synthesis of Fe 3 O 4 -silica core-shell nanoparticles with hierarchically ultra-large pores independent of any post-treatment such as annealing and template-molecule removal.
ISSN:0959-9428
1364-5501
DOI:10.1039/c2jm31749d