Pathways involved in sunburn cell formation: deregulation in skin cancer

The incidence of squamous cell carcinoma of the skin is rising worldwide for decades. Chronic exposure to sunlight is the most important environmental risk factor for this type of skin cancer. This is predominantly due to the DNA damaging effect of ultraviolet-B (UVB) in sunlight. UVB induces also s...

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Bibliographic Details
Published in:Photochemical & photobiological sciences 2006-02, Vol.5 (2), p.199-207
Main Authors: Claerhout, Sofie, Van Laethem, An, Agostinis, Patrizia, Garmyn, Marjan
Format: Article
Language:English
Subjects:
Apoptosis - radiation effects
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - metabolism
Cell Survival - radiation effects
Humans
Keratinocytes - metabolism
Keratinocytes - radiation effects
Neoplasms, Radiation-Induced - metabolism
Signal Transduction - radiation effects
Skin Neoplasms - metabolism
Ultraviolet Rays - adverse effects
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Summary:The incidence of squamous cell carcinoma of the skin is rising worldwide for decades. Chronic exposure to sunlight is the most important environmental risk factor for this type of skin cancer. This is predominantly due to the DNA damaging effect of ultraviolet-B (UVB) in sunlight. UVB induces also sunburn cells, i.e. apoptotic keratinocytes, which is a crucial protective mechanism against the carcinogenic effects of UVB irradiation. This process is regulated by a wide range of molecular determinants involved in the balance between pro- and anti-apoptotic pathways. Growing evidence suggests that the deregulation of this balance by chronic UVB irradiation, contributes to the development of skin cancer. This review gives a brief summary of major known pathways involved in the regulation of keratinocyte survival and cell death upon UVB damage and discusses the contribution of the deregulation of these cascades to photocarcinogenesis.
ISSN:1474-905X
1474-9092
DOI:10.1039/b504970a