Snowflake-shaped poly(3-thiophenemalonic acid) combined with carbonized ZIF-8@ZIF-67 hollow polyhedra for sensitive electrochemical detection of metronidazole

Developing a facile and effective assay method is crucial due to the potential harm of metronidazole (MNZ) antibiotics to both human health and the environment. Herein, snowflake-shaped poly(3-thiophenemalonic acid, 3-TPA) combined with a carbonized core-shell-type ZIF-8@ZIF-67 (C-ZIF-8@ZIF-67) holl...

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Bibliographic Details
Published in:New journal of chemistry 2024-07, Vol.48 (27), p.12387-12398
Main Authors: Jin, Yafeng, Han, Fangming, Wang, Tao, Shi, Haofu, Li, Xiaobo, Yang, Li, Chen, Na, Yang, Kaifeng, Song, Xinyue, Xu, Guangri
Format: Article
Language:English
Subjects:
Chemical reduction
Density functional theory
Effectiveness
Electrochemical analysis
Glassy carbon
Polyhedra
Polymerization
Snowflakes
Synergistic effect
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Summary:Developing a facile and effective assay method is crucial due to the potential harm of metronidazole (MNZ) antibiotics to both human health and the environment. Herein, snowflake-shaped poly(3-thiophenemalonic acid, 3-TPA) combined with a carbonized core-shell-type ZIF-8@ZIF-67 (C-ZIF-8@ZIF-67) hollow polyhedra modified glassy carbon electrode (GCE), denoted as C-ZIF-8@ZIF-67/P3TPA/GCE, was fabricated by electropolymerization followed by the electrodeposition strategy. The resulting sensor demonstrates a significant electrocatalysis effect for the reduction reaction of MNZ, exhibiting a broad linear range (0.1-20, 20-800 μM) with a low limit of detection (LOD, 3S/N) of 0.024 μM. Furthermore, it has been successfully applied to determine MNZ in tablets and lake water. A synergistic effect between P3TPA and C-ZIF-8@ZIF-67 is elucidated through density functional theory (DFT) calculations. Consequently, this research introduces a sensitive and effective method for monitoring MNZ in real samples. A sensitive MNZ sensor based on snowflake-shaped poly(3-thiophenemalonic acid, 3-TPA) combined with C-ZIF-8@ZIF-67 hollow polyhedra.
ISSN:1144-0546
1369-9261
DOI:10.1039/d4nj01982b