Organophotoelectrocatalytic C(sp)-H alkylation of heteroarenes with unactivated C(sp)-H compounds

An organophotoelectrocatalytic method for the C(sp 2 )-H alkylation of heteroarenes with unactivated C(sp 3 )-H compounds through dehydrogenation cross-coupling has been developed. The C(sp 2 )-H alkylation combines organic catalysis, photochemistry and electrochemistry, avoiding the need for extern...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-05, Vol.6 (42), p.552-555
Main Authors: Wan, Qinhui, Wu, Xia-Die, Hou, Zhong-Wei, Ma, Yongmin, Wang, Lei
Format: Article
Language:English
Subjects:
Alkylation
Cross coupling
Dehydrogenation
Electrochemistry
Functional groups
Oxidizing agents
Photochemistry
Reagents
Substrates
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Summary:An organophotoelectrocatalytic method for the C(sp 2 )-H alkylation of heteroarenes with unactivated C(sp 3 )-H compounds through dehydrogenation cross-coupling has been developed. The C(sp 2 )-H alkylation combines organic catalysis, photochemistry and electrochemistry, avoiding the need for external metal-reagents, HAT-reagents, and oxidants. This protocol exhibits good substrate tolerance and functional group compatibility, providing a straightforward and powerful pathway to access a variety of alkylated heteroarenes under green conditions. An organophotoelectrocatalytic method for the C(sp 2 )-H alkylation of heteroarenes with unactivated C(sp 3 )-H compounds via dehydrogenation cross-coupling was developed.
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc01335b