Phenylboronic acid modification-based novel dumbbell-shaped Au-Ag nanorod SERS substrates for ultrasensitive detection of SO 4 2

Based on the coordination principle of Lewis acids, a 4-mercaptophenylboronic acid (4-MPBA)-modified novel dumbbell-shaped Au-Ag nanorod (4-MPBA@DS Au-AgNR) substrate was developed, which could be combined with the surface-enhanced Raman scattering (SERS) technique to detect SO with high sensitivity...

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Published in:Analytical methods 2024-04, Vol.16 (15), p.2311-2321
Main Authors: Shen, Kang, Bi, Caili, Yang, Haifan, Xu, Miaowen, Huang, Lili, Wang, Youwei
Format: Article
Language:English
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Summary:Based on the coordination principle of Lewis acids, a 4-mercaptophenylboronic acid (4-MPBA)-modified novel dumbbell-shaped Au-Ag nanorod (4-MPBA@DS Au-AgNR) substrate was developed, which could be combined with the surface-enhanced Raman scattering (SERS) technique to detect SO with high sensitivity and specificity. DS Au-AgNRs synthesized in this study with a dumbbell-shaped structure were verified by finite-difference time domain (FDTD) simulation to be capable of stimulating strong localized electromagnetic enhancement (EM) at nano-edge and gap, generating a large number of "hot spots" exhibiting excellent SERS performance. The 4-MPBA modified on its surface could specifically recognize SO , producing a change in the spectral peak at 1382 cm , thus realizing highly sensitive and specific sensing of SO . Under optimized conditions, this SERS sensor responded rapidly to SO within 2 minutes and demonstrated outstanding specificity. Calculation of the ratio of the characteristic peaks at 1382 and 1070 cm ( / ) enabled the quantitative detection of SO in the range of 1 × 10 -1 × 10 M, and the detection threshold was as low as 1 nM, which was superior to those of similar detection methods. Importantly, the utility and reliability of this SERS substrate for the determination of SO in actual samples were evaluated using ion chromatography as the gold standard, and there was no significant difference between the two protocols ( > 0.05), and the RSD was less than 6% with a satisfactory recovery rate (97.6-102.3%). Therefore, the present protocol has the advantages of simplicity and rapidity, high sensitivity, specificity, stability, and practicability in the determination of SO in aqueous solution, providing a reliable solution for tracing SO in the fields of food safety and environmental testing.
ISSN:1759-9660
1759-9679
DOI:10.1039/D3AY01831H