Rapid detection of major Gram-positive pathogens in ocular specimens using a novel fluorescent vancomycin-based probe

Bacterial infections of the eye are significant causes of morbidity that can lead to permanent visual loss without rapid and adequate treatment, with Gram-positive bacteria causing the majority of ocular infections. Here we report a novel probe, based on the reductive amination of vancomycin with a...

Full description

Saved in:
Bibliographic Details
Published in:Sensors & diagnostics 2022-09, Vol.1 (5), p.1014-1020
Main Authors: Sharma, Richa, Rajagopalan, Harinee, Klausen, Maxime, Jeyalatha, Mani Vimalin, Üçüncü, Muhammed, Venkateswaran, Seshasailam, Anand, Appakkudal R., Bradley, Mark
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bacterial infections of the eye are significant causes of morbidity that can lead to permanent visual loss without rapid and adequate treatment, with Gram-positive bacteria causing the majority of ocular infections. Here we report a novel probe, based on the reductive amination of vancomycin with a 4-nitrobenzoxadiazole (NBD)-based aldehyde, that rapidly and specifically detects Gram positive infections from ocular samples.
ISSN:2635-0998
2635-0998
DOI:10.1039/D2SD00061J