Reversible regulation of metallo-base-pair interactions for DNA dehybridization by ultrasound

Mechanical force applied by ultrasound in solution leads to the dissociation of DNA metallo-base-pair interactions when these motifs are functionalized with oligodeoxynucleotide sequences of sufficient length. The annealing and force-induced denaturing process is followed by the attachment of distan...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-07, Vol.57 (6), p.7438-744
Main Authors: Huo, Shuaidong, Zhou, Yu, Liao, Zhihuan, Zhao, Pengkun, Zou, Miancheng, Göstl, Robert, Herrmann, Andreas
Format: Article
Language:English
Subjects:
Fluorescent indicators
Metallography
Ultrasonic imaging
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Summary:Mechanical force applied by ultrasound in solution leads to the dissociation of DNA metallo-base-pair interactions when these motifs are functionalized with oligodeoxynucleotide sequences of sufficient length. The annealing and force-induced denaturing process is followed by the attachment of distance-sensitive fluorescent probes and is found to be reversible. Ultrasound leads to the reversible dissociation of DNA metallo-base-pairs when these motifs are functionalized with oligodeoxynucleotide sequences of sufficient length.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc02402g