A two-step gas/liquid strategy for the production of N-doped defect-rich transition metal dichalcogenide nanosheets and their antibacterial applications

Herein, we developed a general two-step gas expansion and exfoliation strategy based on a urea-assisted hydrothermal process combined with sonication exfoliation for the production of nitrogen (N)-doped plus defect-rich transition metal dichalcogenide (TMD) nanosheets (NSs) such as N-MoS 2 and N-WS...

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Bibliographic Details
Published in:Nanoscale 2020-04, Vol.12 (15), p.8415-8424
Main Authors: Wang, Tao, Zhang, Xiao, Mei, Linqiang, Ma, Dongqing, Liao, You, Zu, Yan, Xu, Peng, Yin, Wenyan, Gu, Zhanjun
Format: Article
Language:English
Subjects:
Ammonia
Ampicillin
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antiinfectives and antibacterials
Bacteria
Bacteria - drug effects
Catalysis
Catalytic activity
Chalcogenides
Chalcogens - chemistry
Chalcogens - pharmacology
Defects
Distilled water
Disulfides - chemistry
Disulfides - pharmacology
E coli
Exfoliation
Gas expansion
Hydrogen peroxide
Hydrogen Peroxide - chemistry
Hydroxyl radicals
Interlayers
Mice
Molybdenum - chemistry
Molybdenum - pharmacology
Molybdenum disulfide
Nanosheets
Nanostructures - chemistry
Nitrogen
Nitrogen - chemistry
Nitrogen - pharmacology
Peroxidase
Peroxidase - pharmacology
Strategy
Surface Properties
Transition Elements - chemistry
Transition Elements - pharmacology
Transition metal compounds
Tungsten disulfide
Urea - chemistry
Ureas
Wound healing
Wound Infection - drug therapy
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Summary:Herein, we developed a general two-step gas expansion and exfoliation strategy based on a urea-assisted hydrothermal process combined with sonication exfoliation for the production of nitrogen (N)-doped plus defect-rich transition metal dichalcogenide (TMD) nanosheets (NSs) such as N-MoS 2 and N-WS 2 NSs. The interlayers of bulk MoS 2 (or WS 2 ) were expanded with urea molecules dissolved in distilled water, which were decomposed to NH 3 during the hydrothermal process. Simultaneously, sulfur atoms were partly replaced by N atoms to achieve N doping. Subsequently, sonication exfoliation of the urea-treated bulk MoS 2 (or WS 2 ) promoted the production of defect-rich NSs. Importantly, the defect-rich N-MoS 2 and N-WS 2 NSs exhibit enhanced peroxidase-like catalytic activity after being captured by bacteria, and can catalyze hydrogen peroxide (H 2 O 2 ) to produce more toxic hydroxyl radicals (&z.rad;OH) than non-N-doped MoS 2 or WS 2 NSs. As a result, the N-MoS 2 or N-WS 2 NSs were capable of effectively killing Gram-negative ampicillin resistant Escherichia coli (Amp r E. coli ) and Gram-positive endospore-forming Bacillus subtilis ( B. subtilis ) and promoting bacteria-infected wound healing. This work not only provides a simple, universal exfoliation strategy for producing defect-rich N-doped TMD NSs but also provides a promising catalytic antibacterial option and has potential for many other catalytic applications. A simple two-step strategy based on gas expansion combined liquid exfoliation to synthesize defect-rich N-doped MoS 2 and N-doped WS 2 nanosheets (NSs) was proposed. The NSs with improved peroxidase-like catalytic activity can be applied as effective nanoantimicrobials.
ISSN:2040-3364
2040-3372
DOI:10.1039/d0nr00192a