NIR responsive AuNR/pNIPAM/PEGDA inverse opal hydrogel microcarriers for controllable drug delivery

Particle-based delivery systems have emerged as a powerful platform in controlled drug release. In the present study, we developed a new inverse opal hydrogel microcarrier system composed of gold nanorods (AuNRs) for near-infrared light (NIR) activated drug delivery. AuNRs with a desired aspect rati...

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Bibliographic Details
Published in:New journal of chemistry 2021-05, Vol.45 (17), p.7893-7899
Main Authors: Liu, L. Z, Sun, X. Y, Yan, Z. Y, Ye, B. F
Format: Article
Language:English
Subjects:
Aspect ratio
Beads
Drug delivery systems
High temperature effects
Hydrogels
Nanorods
Near infrared radiation
Polyisopropyl acrylamide
Silicon dioxide
Stability
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Summary:Particle-based delivery systems have emerged as a powerful platform in controlled drug release. In the present study, we developed a new inverse opal hydrogel microcarrier system composed of gold nanorods (AuNRs) for near-infrared light (NIR) activated drug delivery. AuNRs with a desired aspect ratio were prepared by a seed-mediated growth method. The inverse opal hydrogel microcarriers composited with AuNRs were synthesized by negatively replicating silica colloidal crystal beads (SCCBs). The NIR-thermo response of the microcarriers was due to the NIR photothermal heating effect of AuNRs and the thermo responsive volume transition of poly( N -isopropylacrylamide) (pNIPAM) hydrogel. It was found that the NIR-controlled reversible shrinking response of the microcarriers was ideal for the controllable drug release with real-time self-reporting color indication. A novel inverse opal microcarrier with both NIR-controlled release and visual color changes for drug delivery.
ISSN:1144-0546
1369-9261
DOI:10.1039/d0nj06289h