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Fabrication and characterization of polylactic acid/polycaprolactone composite macroporous micro-nanofiber scaffolds by phase separation
The realization of a three-dimensional (3D) composite nanofiber scaffold in bone tissue engineering is promising and challenging. In this paper, a series of biodegradable polylactic acid (PLA)/polycaprolactone (PCL) composite micro-nanofiber scaffolds with different PCL contents (0-50 wt%) were prep...
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Published in: | New journal of chemistry 2020-10, Vol.44 (4), p.17382-1739 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The realization of a three-dimensional (3D) composite nanofiber scaffold in bone tissue engineering is promising and challenging. In this paper, a series of biodegradable polylactic acid (PLA)/polycaprolactone (PCL) composite micro-nanofiber scaffolds with different PCL contents (0-50 wt%) were prepared by phase separation. The results showed that the addition of PCL had a great effect on the morphology of composite scaffolds and also changed the thermal properties and crystallinity of the PLA matrix. Meanwhile, the addition of the PCL content less than 30% could improve the compressive modulus of the PLA/PCL composite scaffold but slightly reduce the compressive strength. However, a higher content of PCL caused macroscopic collapse of the composite scaffold, which gradually deteriorated the mechanical properties of the scaffolds. The apatite formation ability,
in vitro
cell proliferation and degradation experiments showed that the PLA/PCL composite scaffold with 30% PCL has good bioactivity, cytocompatibility and degradation rate compared to the pure PLA scaffold just due to the biomimetic ECM nanofiber structure.
By using incompatible polymers, the preparation of scaffolds with a macroporous structure has overcome the use of porogens and carcinogenic solvents. |
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ISSN: | 1144-0546 1369-9261 |
DOI: | 10.1039/d0nj03176c |