A visible-light photoactivatable di-nuclear Pt IV triazolato azido complex

A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5'-guanosine monophosphate (5�...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-09, Vol.55 (75), p.11287-11290
Main Authors: Yao, Kezi, Bertran, Arnau, Howarth, Alison, Goicoechea, Jose M, Hare, Samuel M, Rees, Nicholas H, Foroozandeh, Mohammadali, Bowen, Alice M, Farrer, Nicola J
Format: Article
Language:English
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Summary:A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5'-guanosine monophosphate (5'-GMP) produced both PtIV and PtII 5'-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals. Spin-trapping of photogenerated radicals - particularly hydroxyl radicals - was significantly reduced in the presence of 5'-GMP.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc05310g